Before setting of tadalafila it is necessary to pay attention to the following:
Kidney insufficiency (see is “Method of application and dose”). On a background tadalafila for patients with kidney insufficiency of middle degree of weight (Cl of kreatinina 31–50 ml/mines) pain was more frequent marked in the back as compared to patients with easy kidney insufficiency (Cl of kreatinina 51–80 ml/mines) or with healthy volunteers.
In клинико-pharmacological researches (N=28) at the dose of tadalafila 10 mgs for patients with kidney insufficiency of middle degree of weight (Cl of kreatinina 31–50 ml/mines) pain was more frequent marked in the back as compared to patients with easy kidney insufficiency (Cl of kreatinina 51–80 ml/mines) or with healthy volunteers. At a dose 5 mgs frequency and
expressed pain in the back did not differ mean
As well as other ingibitory of FDE5, tadalafil possesses properties of weak system vazodilatatora, that can bring HELL over to the brief decline (see “Pharmacology”, Influence on HELL).
Safety and efficiency of tadalafila at a simultaneous reception with other facilities for treatment of erektil’noy disfunction, not studied, a simultaneous reception was not recommended.
Tadalafil did not apply for patients with the promoted propensity to bleeding or with active pepticheskaya an ulcer. Although tadalafil does not multiply bleeding time for healthy volunteers, at his use for patients with the promoted propensity to bleeding or with an active pepticheskoy ulcer it is necessary to estimate correlation risk/benefit.
Application for the patients of sear and yellow leaf. In clinical researches of tadalafila approximately 25% men were in age a chief 65 years.