Method of application and dose: Inward, regardless of reception squeak, an initial dose is 20 mgs. Patients can carry out the attempt of sexual intercourse during 36 ch after a reception for establishment of optimum time of answer for adopting preparation. Maximal recommended frequency of reception — 1 time per days.
For the men of sear and yellow leaf (65 years and more senior) of adjustment of dose not required.
Kidney insufficiency. For patients with insignificant violation of function of buds of change of the mode of dosage not required.
At moderate kidney insufficiency (Cl of kreatinina 31–50 ml/mines) the initial recommended dose is a no more than 5 mg in a day, a maximal dose is a no more than 10 mg each 48 ch. At heavy kidney insufficiency for patients on gemodialize the maximal recommended dose is a no more than 5 mg in a day (see is “Pharmacology”, Decline of function of buds).
Violation of function of liver. At hepatic insufficiency of weak and middle degree of expressed a maximal dose is 10 mgs 1 time per days. At heavy hepatic insufficiency the use of preparation is not recommended, as information of the controlled clinical researches is absent on safety of application (see is “Pharmacology”, Decline of function of liver).
Concomitant therapy: for patients, adopting strong ingibitory of CYP3A4 (for example ketokonazol, ritonavir and other.
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