By-effects, observed in platsebo-kontroliruemykh clinical tests
Side effect of Platsebo (N=476), % Tadalafil 5 mgs (N=151), % Tadalafil 10 mgs (N=394), %
Tadalafil 20 mgs (N=635), %
Head pain 5 11 11 15
Dyspepsia 1 4 8 10
Pain in the back 3 3 5 6
Myalgia 1 1 4 3
Zalozhennost’ of nose 1 2 3 3
Waves 1 2 3 3
Pain in extremities 1 1 3 3
Pain in the back or myalgia was marked with frequency, presented in a table.
In clinical tests tadalafila pain in the back or myalgia, as a rule, showed up through 12–24 ch after a reception and usually passed during 48 ch. Pain is in спине/миалгия, related to adopting tadalafila, characterized as diffuse two-sided pains at the bottom of small of the back, buttocks, thighs or as torakolyumbarnyy myshechnyy discomfort and intensifying in lying position. Usually pain was the insignificant or middle degree of expressed and passed without medicinal treatment, the expressed pain in the back was marked rarely (<5% all reports). At a necessity treatment usually paratsetamol appeared effective or NPVS, however used a codeine was in the small number of cases. On the whole, approximately 0,5% all patients, accepting tadalafil, halted treatment from pain in the back/myalgia. Diagnostic research, including the estimation of inflammation, myshechnoy trauma or defeat of buds, did not expose meaningful medical information, lyings in basis of pathology.
From the side of the serdechno-sosudistoy system: stenokardiya, pain in a breast, gipotenziya, gipertenziya, heart attack of miokarda, ortostaticheskaya gipotenziya, palpitation, sinkopal’nye states, takhikardiya.
From the side of organs of ZHKT: change of functional hepatic tests, diareya, dryness in to the mouth, disfagiya, ezofagit, gastroezofageal’nyy reflyuks, gastritis, increase of level of gamma-glutamiltranspeptidazy,
liquid chair, nausea, pain vverkhu a stomach, vomiting.
From the side of oporno-dvigatel’nogo vehicle: artralgiya, pain is in a neck.
From the side of the nervous system: dizziness, gipesteziya, insomniya, paresteziya, somnolence, vertigo.
From the side of the respirator system: dispnoe, nose-bleed, pharyngitis.