Cialis is strong, selective ingibitor of recurrent action of cyclic guanozinmonofosfat specific fosfodiesturazy 5 type (PDE5).
The main stage in penile erection is relaksatsiya of cages of smooth musculature of corpus cavernosum, which is locally caused by atsetilkholin and oxide of nitrogen,
and also other physiological agents.
Atsetilkholin is selected by the neurons of the parasimpaticheskoy nervous system. The oxide of nitrogen is made by неадренергические, нехолинергические neurons and cages of endoteliya as a result of hormonal stimulation. A net effect removes tone of the simpaticheskoy nervous system or stimulations which causes reductions of cages of smooth musculature and a cock saves in the unexcited state.
Cyclic guanozinmonofosfat (cGMF) and PDE5 act important part in normal erektil’noy fukntsii. CGMF causes expansion of arteries and strengthens the influx of blood in corpus cavernosum.